The Mystery Chronic Cough (a.k.a. habit cough, tic cough, psychogenic cough, irritable larynx syndrome)

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coughing manThere are patients with a mysterious chronic dry cough (longer than 6 months) that seems to defy all explanation and resist all the usual standard treatments. Some of these patients have coughed for more than ten years resulting in frustration not only in terms of treatment, but diagnosis. Often, patients are told their cough is due to reflux, allergy, asthma, infection, aspiration, virus, etc and undergo numerous exams and studies including pulmonary function tests, chest x-rays, reflux studies, barium swallows, upper endoscopy, CT scans, MRI scans, etc. Even all medications known to cause a cough as a side effect (ie, statins, ACE Inhibitors and Angiotensin Receptor Blockers) are removed to no avail. More often than not, all these medical studies come back normal. Furthermore, proposed treatments with antibiotics, proton pump inhibitors, allergy medications, cough suppressants, steroid inhalers, etc are not successful. Surgery may even be performed which also fails to improve the cough. Eventually, some are even told it's all in their head (psychogenic cough, habit cough, tic cough, etc) or idiopathic.

A typical patient with the chronic cough is described as follows:

  • Started during or after recovering from a viral laryngitis and/or upper respiratory infection
  • Dry cough
  • Cough occurs due to no perceivable reason...perhaps only a tickle
  • Cough may occur several times an hour to even as often as several times a minute. Must be distinguished from whooping cough (severe attacks of a choking cough that lasts 1-2 minutes often with near vomiting and appearance of suffocation. Watch Mayo Clinic video).
  • Cough does not seem to get better with time (months or even years)
  • All diagnostic studies performed come back normal
  • Endoscopy of the throat and voicebox is normal (this exam will be performed on the first visit to ensure that there is no anatomic reason for the cough). Such anatomic factors that may trigger a cough include an elongated uvula as well as large tonsils (Link #1Link #2Link #3Link #4)


If this description sounds like you, you may have chronic cough due to laryngeal sensory neuropathy (aka, sensory neuropathic cough, vagal neuropathy, etc). What does this mean? Essentially, this means that the nerve that provides sensation to the voicebox and is responsible for triggering the cough reflex has been injured, usually by a virus. When this happens, the nerve's level of sensitivity before it triggers the cough reflex becomes markedly reduced; in other words, it becomes hyper-sensitive. This situation is akin to the elevated sensitivity of the skin producing pain even with the lightest touch after healing from a bad burn, even if the skin appears completely normal. Other related forms of such sensory neuropathy include diabetic neuropathy, post-herpetic neuralgia, phantom limb pain, etc.

Normally, the nerve recovers its normal level of sensitivity and the cough resolves. However, in some patients, the nerve does not recover and a persistent chronic cough results. In this scenario, the best medications are those that "calm" the nerve down. Such medications include amitriptyline (elavil), nortriptyline (pamelor, aventyl), tramadol (Ultram), desipramine, pregabalin (lyrica), or gabapentin (neurontin). Read NYT article.

If you are well-versed in medications, you will realize that these are the same medications used to treat various peripheral neuropathies listed in the prior paragraph. Please note that for a given patient, one medication may work better than the other which may not work at all. Trial and error is unfortunately necessary. Also, these medications will NOT help a cough due to an active infection (cold, flu, pneumonia, bronchitis, etc). See references below in how these meds should be taken.

Please note, a workup MUST be performed before this treatment is initiatied as laryngeal sensory neuropathy is a diagnosis of exclusion. However, there is a test that "might" diagnose laryngeal sensory neuropathy called SELSAP. Keep in mind that this test shows promise, but is not totally definitive. Furthermore, all cough triggers would STILL need to be identified mandating a workup. But neuropathy treatment could potentially be started more quickly if SELSAP is positive.

With careful guidance with these medications, the cough signficantly improves and even completely resolves. The medications are taken for 3 to 6+ months after which it is slowly tapered down. Of note, in certain rare situations, vocal cord dysfunction, globus pharyngeus, and chronic throat-clearing are related disorders treated in a similar manner (once reflux and other medical disorders are ruled-out or thoroughly managed).

Patients need to keep in mind that it is not unusual that a patient may have SEVERAL factors of cough as well, all of which need to be treated in order to resolve a persistent cough. For example, reflux and allergies may be present as well as laryngeal sensory neuropathy. Because this disorder results in a hypersensitized larynx, problems with reflux and allergies which ordinarily would not cause a cough in normal patients, will now cause a persistent cough. In other words, though allergy testing may reveal only mild allergies and 24 hour pH impedance study may show reflux episodes within normal range, these "mild" problems now need to be treated aggressively along with the neuropathy. The lack of treatment for each and every known cause of cough (even if mild) is the most common reason why treatment of laryngeal sensory neuropathy fails with neuropathic medication. To reiterate... laryngeal sensory neuropathy is a hypersensitized larynx. In this hypersensitized state, even a little bit of reflux or allergies will trigger a cough which normally would not. Each and every one of these conditions need to be treated. Read more about this scenario here.

In extremely rare situations, botox injections into the vocal cords may help should the medications be found ineffective.

Of note... If it is a child with a chronic cough, there is a VERY rare disorder called PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus) where strep infections can trigger motor tics including chronic cough (or throat clearing) seemingly overnight. If there is concern for this particular disorder, an evaluation with a pediatric neurologist may be warranted. Here is a link to a girl who sneezed constantly due to this disorder. Here is a New York Times article.

If you are a musician playing a wind or brass instrument... your chronic cough could be due to your instrument! Germs have been found inside such instruments that can get inhaled into your lungs causing a pneumonitis resulting in chronic cough. Read more about this here.

If laryngeal sensory neuropathy is affecting your quality of life, please contact our office for an appointment.

PLEASE HAND-BRING the most recent reports and studies listed below (show to your physicians). Even better, please MAIL the records a few weeks before your visit so they can be reviewed prior to your visit to save time.

These records are ESSENTIAL and each of these studies should be done (generally speaking, though there are exceptions) prior to determining whether you may or may not have laryngeal sensory neuropathy.

  • Vitamin B12 supplementation if deficient (read report on this)
  • Bordetella serum titres
  • SELSAP Study (Surface Evoked Laryngeal Sensory Action Potential)
  • GI Workup
    • Esophagoscopy (Evaluate for esophageal pathology. In rare cases, mucosal ulcers have been found hypothesized to irritate the recurrent laryngeal nerve, found alongside the esophagus, resulting in cough). Watch video.
    • Barium swallow (Evaluate for esophageal motility problems as well as Zenker's diverticulum). Watch video on this test.
    • 24-Hour Multichannel Intraluminal Impedance (MII) and pH monitoring with manometry (Evaluate for acid as well as non-acid reflux). Watch video on how this is performed. Please note that BRAVO and other types of pH studies are NOT good enough.
    • Response after maximum reflux medication treatment
    • In the near future, a rapid spit test can be performed to determine if reflux is present as well.
  • Allergy Workup
    • CT Sinus scan (Evaluate for subclinical chronic sinusitis)
    • Allergy testing (Evaluate for allergies). If positive, allergy injection response report
  • Pulmonary Workup
    • Pulmonary function test with methacholine challenge (Evaluate for reactive airway disease)
    • FeNO (Fraction of Exhaled Nitric Oxide) if possible as not many places offer this (another measure for reactive airway disease). Closest places that offer this test can be found here.
    • Bronchoscopy with lavage cultures (Evaluate for subclinical pulmonary infections/masses/reactive airway disease)
    • CT Chest scan (Evaluate for lung masses too small to be seen on Chest X-ray)
    • Response to asthma medications
    • Sleep Study to evaluate for obstructive sleep apnea (read report on this)

Related Blog Articles

References

  • Amitriptyline for symptomatic treatment of idiopathic chronic laryngeal irritability. Ann Otol Rhinol Laryngol. 2013 Jan;122(1):20-4. Link
  • Use of specific neuromodulators in the treatment of chronic, idiopathic cough: a systematic review. Otolaryngol Head Neck Surg. 2013 Mar;148(3):374-82. doi: 10.1177/0194599812471817. Epub 2013 Jan 8. Link
  • Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. The Lancet. Aug 28, 2012. doi:10.1016/S0140-6736(12)60776-4. Link
  • Management of Recurrent Laryngeal Sensory Neuropathic Symptoms. Norris BK, Schweinfurth JM. Ann Otol Rhinol Laryngol. 2010; 119:188-191. Link
  • Chronic cough as a sign of laryngeal sensory neuropathy: diagnosis and treatment. Lee B, Woo P. Ann Otol Rhinol Laryngol. 2005 Apr;114(4):253-7. Link
  • Gabapentin in the Treatment of Intractable Idiopathic Chronic Cough. Mintz S, Lee JK. Am J Med. 2006; 119(5):e13-15. Link
  • Laryngeal Neuropathy as a Cause of Chronic Intractable Cough. Mishriki YY. Am J Med. 2006; 119(5):e5. Link
  • Sensory neuropathic cough: a common and treatable cause of chronic cough. Bastian RW, Vaidya AM, Delsupehe KG. Otolaryngol Head Neck Surg. 2006 Jul;135(1):17-21. Link
  • Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. 2006. Jeyakumar A, Brickman TM, Haben M. Laryngoscope 116(12):2108-2112. Link
  • The irritable larynx syndrome. Morrison M, Rammage L, Emami AJ. Journal of Voice. 1999;13:447-55. Link
  • Vagal neuropathy after upper respiratory infection: a viral etiology? Amin MR, Kaufman JA. American Journal of Otolaryngology, 2001;22(4):251-256. Link
  • Cough and paradoxical vocal fold motion. Altman KW, Simpson CB, Amin MR. Otolaryngology-Head & Neck Surgery. 2002;127(6):501-11. Link
  • Botulinum Toxin A: A novel adjunct treatment for debilitating habit cough in children. Sipp JA, Haver KE, Masek BJ, Hartnick CJ. ENT Journal 2007;86(9):570-572. Link
  • Use of botulinum toxin type A for chronic cough: a neuropathic model. Archives of Otolaryngology-Head & Neck Surgery. 2010;136(5):447-452. Link
  • A new treatment option for laryngeal sensory neuropathy. Halum SL, Sycamore DL, McRae BR. Laryngoscope. 2009. Link
  • Postviral vagal neuropathy. Rees CJ, Henderson AH, Belafsky PC. Annals Otol Laryngol Rhinol. 118(4):247-52, 2009. Link
  • Vitamin B12 Deficiency and chronic cough and upper airway sensory neuropathy. Chest. 136. 2009. Link


News Article on This Topic

Dr. Chang was featured in a regional quarterly publication addressing Laryngeal Sensory Neuropathy. Click here to read the article (first 2 pages).


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