Tinnitus (Ringing in the Ears)
Tinnitus is the perception of noise heard only by the patient in the absence of sound. Tinnitus is generally divided into three main categories: pulsatile, arrhythmic, and continuous. Differentiation between the three is important as the work-up for treatment is completely different for each.
Pulsatile tinnitus is a generally described as a rhythmic whooshing noise which occurs in time with one's heartbeat (feel your pulse on your neck or wrist and see if it occurs in sync with the noise in the ear). This type of tinnitus mandates a medical work-up with radiological tests (cartoid ultrasound, CTA, MRA/MRV) as well as bloodwork (CBC, TSH). This particular form of tinnitus may be treatable depending on what is ultimately found to be abnormal. Such abnormalities include TMJ, carotid stenosis/dissection, high-riding jugular bulb, vascular hyperdynamic states (hyperthyroid or anemia), intracranial hypertension, etc.
This symptom may also occur if there is a temporary conductive hearing loss due to eustachian tube dysfunction, ear infection, or serous otitis media. In these circumstances, the pulsatile tinnitus should resolve once the ear issue improves and the conductive hearing loss disappears.
Of note, at least in caucasian white females, intracranial hypertension is one of the most common causes of pulsatile tinnitus once middle ear conditions have been ruled out.
Arrhythmic tinnitus has a few causes, some which are easily treatable, and another that may even require surgery. The easily treatable kind is removal of any object that is resting against the eardrum such as a piece of hair or foreign body. The more frustrating kind is when one of the 2 muscles (tensor tympani or stapedius) found in the ear starts twitching, much like the more common eye-twitching. This last cause is often described as "clicks" and occurs intermittently in brief bursts. The only way to treat this if it becomes aggravating enough is to cut the ear muscle which can only be done under surgery by an ear specialist. Read more about this here.
Continuous tinnitus is the most common form of tinnitus and is the hardest to treat. Patients often describe this as a high-pitch noise that is continuously there, especially when it's very quiet (such as when trying to go to sleep at night). An audiogram is first obtained to determine whether any hearing abnormalities are present. Subsequently, radiological studies (MRI of the IAC) may also be ordered if any asymmetry is noted. However, most continuous tinnitus is due to nerve-damaged hearing loss. This situation is analogous to phantom limbs after extremity amputations. Hearing loss is the "amputation" and tinnitus is the phantom limb. Another common cause is due to TMJ oddly enough through a mechanism that is not entirely clear. Eliminating salt, caffiene, and alcohol have been found to be helpful in reducing the severity of tinnitus. However, if tinnitus has been present for years, stopping caffiene may make it worse.
If hearing loss is present, hearing aids may be quite helpful. Otherwise, an easy way to address this problem is to have white noise in the environment continuously whether it be a fan running or having the radio tuned to a station where there's static. One can even buy "noise-makers" (also known as tinnitus maskers) specifically to address this problem, though some patients find the noise-makes just as aggravating as the tinnitus itself. Below are listed a few found on Amazon.com.
There is unfortunately no 100% definitive treatment for continuous tinnitus although various new treatments are being studied. One promising treatment with improvement or cure rates approaching 80% is neuromonics. Another tinnitus treatment we currently offer is intra-tympanic steroid injections in certain eligible patients in which the onset of tinnitus was sudden (within the last 10 days) and associated with hearing loss.
In those where the tinnitus has been present for a long time, low-dose of amitriptyline or melatonin may be quite helpful.
Many patients have tried pills such as multi-vitamins, mineral supplements, and other forms of herbal medicine with some success. However, none of the treatments have been found to be as effective as a plain placebo (sugar pill). In such studies, tinnitus was found to get better in 20-30% of patients taking a placebo which was no better than the drug under investigation. Such a response does point to an underlying mental factor contributing to the continuous tinnitus. It also brings business to companies hoping to cash in on the hopes of tinnitus sufferers buoyed by the success of the 20-30% of patients who do respond to these pills (which may as well be a sugar pill).
Here is a table of supplements/medications that have been tried along with research to test their effectiveness in the treatment of continuous tinnitus (info collected from this review paper):
|Drug||Research That Supports||Research That Disputes||Conclusion|
|Lidocaine / Tocainide||#1, #2, #3, #4, #5, #6,||#1, #2, #3, #4||Not appropriate for long-term use.|
|Benzodiazepines (alprazolam, diazepam, clonazepam)||#1, #2, #3, #4||#1, #2, #3||Caution due to addiction and may worsen tinnitus if stopped.|
|Antidepressants (nortriptyline, amitriptyline, trimipramine, sertraline, paroxetine)||#1, #2, #3, #4, #5||#1, #2, #3, #4, #5, #6||TCA may benefit only in patients with depression symptoms|
|Anticonvulsants (carbamazepine, gabapentin, vigabatrin, tiagabine)||#1, #2, #3, #4, #5, #6, #7, #8, #9||#1, #2, #3, #4, #5, #6, #7||Mixed results|
|Antiglutamatergics (caroverine, memantine, acamprosate)||#1, #2, #3, #4||#1, #2, #3, #4||No conclusion.|
|(Anti)Dopaminergics (sulpiride, piribedil)||#1, #2, #3||#1||Studies are weak.|
|Ginkgo Biloba||#1, #2||#1, #2, #3||Not effective.|
|Melatonin||#1, #2, #3||#1||Potentially helpful.|
|Zinc||none||#1, #2, #3, #4||Not effective.|
|Misoprostol||#1, #2||Maybe. More study needed.|
|Furosemide||#1||#1, #2||Not effective|
|Mannitol, Glycerol||#1||Not effective|
|Cyclandelate||#1||#1||Probably not effective|
|Botox||#1, #2||Maybe. More study needed.|
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